The GWDG has a long history of providing supercomputing resources to the researchers and students of the University of Göttingen and of the Max Planck Institutes. The Scientific Compute Cluster (SCC) is constantly extended and upgraded through diverse funding rounds and sub-systems of research groups.

In addition, the GWDG hosts two supercomputers for different user groups. Since 2018 the GWDG operates the Tier-2 system Emmy (HLRN-IV). Since October 2020, the second phase has been in operation, which made it necessary to move to a modular data center. Since 2021 GWDG and the University of Göttingen form one of eight Centers for National High Performance Computing (NHR Centers) nationwide, making Emmy an NHR system, being operated for the northern German states of the HLRN.

In June 2018, the University of Göttingen, the German Aerospace Center ("Deutsches Zentrum für Luft- und Raumfahrt" - DLR) and the GWDG signed a declaration of intent regarding a closer cooperation in compute- and data-have intensive research. The DLR HPC resources are now distributed over two sites: one in Dresden, one in Göttingen.